CR1 mediates binding of L. major metacyclic promastigotes to human macrophages
نویسندگان
چکیده
منابع مشابه
Transformation of Leishmania mexicana metacyclic promastigotes to amastigote-like forms mediated by binding of human C-reactive protein.
Infective metacyclic promastigote forms of Leishmania mexicana are introduced by the bite of sandfly vectors into their human hosts where they transform into the amastigote form. The kinetics of this process was examined in vitro in response to different combinations of temperature (26 degrees C or 32 degrees C), pH (7.2 or 5.5), and exposure to human serum. Little transformation occurred at 26...
متن کاملTransmission of Leishmania metacyclic promastigotes by phlebotomine sand flies
A thorough understanding of the transmission mechanism of any infectious agent is crucial to implementing an effective intervention strategy. Here, our current understanding of the mechanisms that Leishmania parasites use to ensure their transmission from sand fly vectors by bite is reviewed. The most important mechanism is the creation of a "blocked fly" resulting from the secretion of promast...
متن کاملManganese and Iron Binding to Human Transferrin
The characteristics of manganese and iron binding to human apotransferrin (apo-tf) have been investigated and compared in this study. Both metal ions were taken up by human apo-tf and formed complexes, with the maximum absorbances observed at 410 and 340 nm for manganese-transferrin (Mn-tf) and 465 nm for iron-transferrin (Fe-tf). Addition of manganese (1.5 µg/ml) to the reaction mixture contai...
متن کاملLeishmania major: promastigotes induce expression of a subset of chemokine genes in murine macrophages.
Recent studies suggest that Leishmania major promastigotes infect cultured macrophages in a stealthy fashion, activating little or no host gene expression and often interfering with the host's ability to respond to further stimulation. Here we examined macrophage transcription at early times following infection, when virulent parasites must execute steps required for survival. Stationary-phase ...
متن کاملInduction of Th1 Cytokines by Live Logarithmic Promastigotes of L. major
The early cytokines production in response to live logarithmic and stationary phase promastigotes of Leishmania major was examined on the peripheral blood cells of the healthy individuals. Whole blood cultures were stimulated by either logarithmic or stationary phase promastigotes. IFN- and IL-10 productions were assessed by specific sandwich ELISA. The results showed that the logarithmic prom...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Memórias do Instituto Oswaldo Cruz
سال: 1988
ISSN: 0074-0276
DOI: 10.1590/s0074-02761988000500047